A true border to border route, US-45 takes the rider from Mobile on the Gulf Coast to the southern shore of Lake Superior. It's a hoot!
Wisconsin border to Ontanogan, MI
Every touring rider to this area should remember to pack and have available rain gear and cold weather gear! Lake Superior is a huge heat sink, and it manages to keep things relatively cool even in summer.
Dual sport riders have many opportunities here by exploring forest roads and a few unpaved county roads. Be aware there are not many motorcycle repair shops in the area. A breakdown can be expensive and time consuming.
If you plan to camp, bring plenty of bug repellent and if you plan on going deep into the woods you would also benefit from a mesh net to wear around your head. Also be cautious of bear and moose, both while hiking and riding. Either of them can cause serious damage if you hit one.
Prices at the gas pump can be as much as 50 or 60 cents per gallon higher than the Milwaukee area. Consider filling up at the gas station operated by casino just north of Watersmeet, it's usually much less expensive than others in the area.